Alkaline phosphatase level (ALP )

Rate: Rs. 200

Sample

This test is done on the Serum of the patient.

Important Facts

1. This is an enzyme present in the blood and its subtypes are present in the liver, intestine bones and placenta.
2. The conditions which will stimulate bone cells leads to increase level of ALP.
3. The liver ALP is increased in biliary obstruction.
4. AP is involved in bone calcification.
5. The stimulus which increases bone activity cause increase in the AP level.So elevated level indicate liver or bone diseases.
6. AP level rises during active bone formation in growth in infants, childrens and adolescents. So they have raised level up to 3 times of the normal than the adults.
7. Pregnancy can also leads to raised leve.

Significance

1. In the absence of bone disease or pregnancy, markedly raised level of Alkaline phosphatase ( around 10 times ) is best marker of liver obstructive pathology.
2. It is 1 to 2 times raised level may be seen in various liver parenchymal diseases like hepatitis and Cirrhosis.
3. Its level may be mildly raised in metastatic diseases of liver.
4. Also increased in bone disease like Pagets disease, healing fractures, Rickets, pregnancy and childhood.
5. There are higher level in child, infant and is 3 times the adult level.
6. It is also raised in oldage and pregnancy.

Normal value varies according to the kit and methodology used.

Birth :( Kingarmstrong unit) 5—15

Female adult :< 350 or 25—100

Male adult : <350 or 25—100